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Biotechnology: Cell Homogenization


Microfluidics offers the biotechnology industry high shear cell disruption capabilties with improved protein recovery and scaleup guaranteed. From the gentle disruption of cultured cells for virus isolation to the challenging rupture of yeast and other fungi, Microfluidics enables leading global biotechs (including four of the top five) to meet diverse and demanding needs.

Tough on Cells, Gentle on Protein

The Microfluidizer processor is more flexible and robust than other technologies, and can be used to rupture a wide variety of cells each with specific shear requirements. By precisely controlling shear, customers are able to use the smallest pressure possible in order to achieve target cell rupture rates. In addition, Microfluidics technology requires fewer passes and effectively cools product with a heat exchanger. All of these factors combine to ensure maximum cell breakage and protein harvesting.

Select Applications Technical Features Benefits to Pharmaceuticals
  • E. coli
  • Yeast cell disruption
  • Algae
  • Mammalian tissue
  • Bacteria
  • Plant
  • Insect
  • Fungi
  • Efficient cell disruption
  • High protein recovery
  • Scalable
  • Fewer passes
  • Less time to operate and clean
  • Repeatable results
  • Supports multiple applications
  • Faster/simplier filtering


The advantage of the Microfluidizer processor is that it allows us to break the e. coli fast, with minimal impact on the cell's internal compartments.Tularik, Inc.


Proven Processing Results

Review results of cell disruption for e. coli and yeast applications ( >90% rupture rates).


Learn More

Contact us to learn about our experience with your application(s) and cell rupture requirements.