The Microfluidizer processor has unparalled results achieving stable emulsions with droplet sizes attainable in the submicron to nanometer range depending on the desired outcome:
Particle Size Reduction
Microfluidizer high shear fluid processors provide unrivaled uniform particle size reduction. Nanoemulsions with small particle sizes increase bioavailability and enable targeting (e.g. cancer drugs getting past the blood-brain barrier and inside cells).
Instability and phase separation of emulsions and suspensions are the critical challenges faced by research and production teams, as most technologies cannot produce the particle size distribution necessary to reach product goals. To overcome these issues, Microfluidizer processors use unique fixed-geometry interaction chambers to reduce particle sizes uniformly and to a level unmatched by other methods. This enables customers to optimize formulations for maximum stability. Further, quality enhancements such as translucent appearances for food or cosmetics products are more efficiently attainable with Microfluidics.
In addition to the inherent cost benefits of developing products with a prolonged shelf life, customers are usually able to reduce the number of passes needed to reach particle size goals as compared to homogenizers, and typically can simplify downstream processing steps, as well. For pharmaceuticals, applications such as vaccine adjuvants are often nanoemulsions which need to be sterile filtered. Uniformly reducing particles to < 200 nm - demonstrated in the Corixa case study and vaccines webinar recording - significantly reduces filter area required. As usual, scaleup is guaranteed, which brings these cost benefits to production volumes.
Proven Processing Results
Curious how your emulsion could be improved with the Microfluidizer processor? Interested in machine specifications and cooling capabilities? Contact us to speak with a Microfluidics expert.