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Microfluidizer® Successfully Processes Liposomes

Liposome Drug Delivery Applications

Liposomes, small spherical lipid vesicles with a bi-layered membrane, are widely utilized in pharmaceutical formulations to:

  • Encapsulate both hydrophilic and hydrophobic therapeutic agents with high efficiency
  • Protect the encapsulated drugs from undesirable effects from external conditions
  • Functionalize certain ligands that target specific cells, tissues and organs of interest
  • Be coated with inert and biocompatible polymers such as polyethylene glycol (PEG), prolonging the liposome circulation half-life in vivo
  • Develop nanoparticle liposomal formulations with the desired composition, size, surface charge and other properties
  • Generate next-generation vaccine adjuvants

Liposome drug delivery applications include treatment for fungal and protozoan infections, influenza, Hepatitis A, malignant lymphomatous meningitis, breast cancer, age-related macular degeneration and more. Clinical trials are under way to test the effectiveness of liposomes to deliver drugs used in the treatment of leukemia, soft-tissue sarcoma, ovarian cancer and Non-Hodgkin lymphoma.

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The Microfluidizer® Processor Solutions for Liposomal Formulation

The Microfluidizer® processor offers an ideal solution for the production of liposomal formulations due to the following advantages:

  • Continuous process
  • Guaranteed scalability using Microfluidizer® interaction chamber technology
  • Optimal temperature control
  • Samples are processed at a constant shear rate
  • Highest shear rate capability of any homogenizer

The Microfluidizer Equipment Results

Microfluidics engineers helped a biotech research company successfully process liposomes using Microfluidizer® equipment. The average particle size was reduced from 394.8 nm to 132.6 nm after one pass, and from 394.8 nm to 107.7 nm after two passes.

Our experts also helped a pharmaceutical customer develop various formulations of a small molecule API liposome for IV drug delivery in the treatment of cancer. Microfluidizer® technology was very successful in creating several liposomal formulations with the target particle size distributions — on both the lab and production scales.

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