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Nanoemulsions

Superior Nanoemulsion Technology Yields Better Products

Superior Nanoemulsion Production

Microfluidizer® processors are capable of producing extremely fine nanoemulsions. If the formulation is well designed, the resulting nanoemulsion will feature extremely small droplet sizes and a narrow distribution, which is ideal for stability and filtration. Microfluidics’ diverse product portfolio offers nanoemulsion technology that can process samples as small as 2 mL, while our fixed-geometry Interaction Chambers ensure that the process can be scaled up to hundreds of liters per hour using our production scale machines. Microfluidizer® processors are designed to be simple to use and to clean, with the option of conforming to stringent cGMP requirements. With our collective 90 years of experience in applications development and machine engineering, we can help you perfect your pharmaceutical nanotechnology and bring your product to market as quickly as possible.

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Proven Processing Solutions

Vaccine Adjuvant Nanoemulsion Collaboration with the Infectious Disease Research Institute (IDRI)

Vaccine Adjuvant Particle SIze Distributions

Vaccine Adjuvant TEM

View the webinar recording with Dr. Chris Fox, Director of Formulations at IDRI


 

Unrivaled Uniform Particle Size Reduction

Pharmaceutical nanotechnology is exemplified by nanoemulsions featuring nano-scale particles, which increase product bioavailability and enable more precise targeting (e.g. cancer drugs that readily cross the blood/brain barrier and penetrate cells). When manufacturing nanoemulsion vaccine adjuvants, we found that emulsions obtained from a Microfluidizer® processor were 18% — 55% smaller than homogenized emulsions using the same energy input. Similarly, the standard deviations of emulsions processed on a Microfluidizer® processor (0.1 – 2.6) were much lower than those of the homogenized emulsions (3.8 – 14.8). Thus, Microfluidizer® nanoemulsion technology is the clearly superior choice when engaging in modern pharmaceutical nanotechnology.

Improved Stability

Instability and phase separation of emulsions and suspensions are critical challenges faced by research and production teams, as most technologies cannot produce the particle size distributions necessary to reach pharmaceutical nanotechnology goals. To overcome these issues, Microfluidizer® processors use unique fixed-geometry interaction chambers to reduce particle sizes uniformly and to a level unmatched by other methods. This superior nanoemulsion technology enables customers to optimize formulations for maximum stability, and to enjoy the cost efficiencies offered by products with an extended shelf life.

Sterile Filtration

Compared to a simple homogenizer, the use of a Microfluidizer® processor typically enables customers to reduce the number of passes needed to reach particle size goals, and to simplify downstream processing steps. Both of these improvements provide cost benefits. Pharmaceutical applications, such as vaccine adjuvants, often feature nanoemulsions that require sterile filtration. Uniformly reducing particles to less than 200 nm significantly reduces the required filter area.

Scalability

Scaleup is guaranteed, bringing cost benefits to production volumes.

Translucent Nanoemulsions

Quality Improvements

Enhancements such as translucent appearances for food or cosmetics products are more efficiently attainable with Microfluidics.

Translucent Nanoemulsions

 

Nanotechnology in Pharmaceutical Applications

Nanoemulsions represent an increasingly important drug delivery mechanism, and Microfluidizer® nanoemulsion technology is ideal for the formulation of sterile, injectable, insoluble drugs. Microfluidizer® processors are able to overcome the limitations of solubility, stability, and sterilization that are inherent when manufacturing conventional emulsions. Here are a few more webinars that detail some of the applications of nanotechnology for pharmaceutical manufacturing.

 

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