Why Polymer Nanoparticles?
The experts at Microfluidics are available to help customers develop polymeric nanoparticle applications using Microfluidizer® technology. We know how to create small, sterile, filterable nanoparticles and we can show you why a Microfluidizer® processor is your best option for manufacturing certain therapeutics.
The benefits of biodegradable polymer nanoparticles include their ability to:
- Deliver a combination of various therapeutic ingredients
- Include targeting moieties
- Protect active ingredients from degradation
- Control the release of ingredients
- Terminally sterilize through filtration
Key Steps in the Process of Polymer Nanoparticle Development
The basic steps in the process are outlined below. Contact us for additional details.
- Water phase: water + surfactant
- Oil phase: water immiscible solvent + polymer + other ingredients (such as actives, contrast agents, etc.)
Factors to be Considered
- Water miscibility
- Boiling point
- Active Pharmaceutical Ingredients (APIs)
- Diagnostic ingredients (such as contrast enhancers)
- Other ingredients (such as para-magnetic particles, metal oxides, etc.)
- Add oil to the water phase
- Mix using a rotor-stator motor to create a stable pre-mix
- Process the pre-mix using a Microfluidizer® homogenizer after considering the critical processing parameters: chamber type, processing pressure, temperature and number of passes
- Solvent can be extracted from the formulation in several ways:
- Allow the solvent to evaporate in a hood while mixing
- Use a solvent-exchange technique, such as a separator funnel or rotary-evaporator
Particle size analysis is often used to evaluate polymer nanoparticles. Utilizing specific analytical techniques, including dynamic light scattering, optical microscopy, and SEM or TEM, we have found that Microfluidizer® technology is able to reduce polymer droplet size significantly after several passes.