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Polymer Nanoparticles

Ideal Technology for Producing Polymer Nanoparticles

Why Polymer Nanoparticles?

The experts at Microfluidics are available to help customers develop polymeric nanoparticle applications using Microfluidizer® technology. We know how to create small, sterile, filterable nanoparticles and we can show you why a Microfluidizer® processor is your best option for manufacturing certain therapeutics.

The benefits of biodegradable polymer nanoparticles include their ability to:

  • Deliver a combination of various therapeutic ingredients
  • Include targeting moieties
  • Protect active ingredients from degradation
  • Control the release of ingredients
  • Terminally sterilize through filtration

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Key Steps in the Process of Polymer Nanoparticle Development

The basic steps in the process are outlined below. Contact us for additional details.

Determine Formulation

  • Water phase: water + surfactant
  • Oil phase: water immiscible solvent + polymer + other ingredients (such as actives, contrast agents, etc.)

Factors to be Considered

  • Water miscibility
  • Boiling point
  • Toxicity
  • Active Pharmaceutical Ingredients (APIs)
  • Diagnostic ingredients (such as contrast enhancers)
  • Other ingredients (such as para-magnetic particles, metal oxides, etc.)

Determine Process

  • Add oil to the water phase
  • Mix using a rotor-stator motor to create a stable pre-mix
  • Process the pre-mix using a Microfluidizer® homogenizer after considering the critical processing parameters: chamber type, processing pressure, temperature and number of passes

Solvent Extraction

  • Solvent can be extracted from the formulation in several ways:
    • Allow the solvent to evaporate in a hood while mixing
    • Use a solvent-exchange technique, such as a separator funnel or rotary-evaporator

Microfluidizer® Results

Particle size analysis is often used to evaluate polymer nanoparticles. Utilizing specific analytical techniques, including dynamic light scattering, optical microscopy, and SEM or TEM, we have found that Microfluidizer® technology is able to reduce polymer droplet size significantly after several passes.

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