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Polymer Nanoparticles

Ideal Technology for Producing Polymer Nanoparticles

Why Polymer Nanoparticles?

The experts at Microfluidics are available to help customers develop polymeric nanoparticle applications using Microfluidizer® technology. We know how to create small, sterile, filterable nanoparticles and we can show you why a Microfluidizer® processor is your best option for manufacturing certain therapeutics.

The benefits of biodegradable polymer nanoparticles include their ability to:

  • Deliver a combination of various therapeutic ingredients
  • Include targeting moieties
  • Protect active ingredients from degradation
  • Control the release of ingredients
  • Terminally sterilize through filtration

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Key Steps in the Process of Polymer Nanoparticle Development

The basic steps in the process are outlined below. Contact us for additional details.

Determine Formulation

  • Water phase: water + surfactant
  • Oil phase: water immiscible solvent + polymer + other ingredients (such as actives, contrast agents, etc.)

Factors to be Considered

  • Water miscibility
  • Boiling point
  • Toxicity
  • Active Pharmaceutical Ingredients (APIs)
  • Diagnostic ingredients (such as contrast enhancers)
  • Other ingredients (such as para-magnetic particles, metal oxides, etc.)

Determine Process

  • Add oil to the water phase
  • Mix using a rotor-stator motor to create a stable pre-mix
  • Process the pre-mix using a Microfluidizer® homogenizer after considering the critical processing parameters: chamber type, processing pressure, temperature and number of passes

Solvent Extraction

  • Solvent can be extracted from the formulation in several ways:
    • Allow the solvent to evaporate in a hood while mixing
    • Use a solvent-exchange technique, such as a separator funnel or rotary-evaporator

Microfluidizer® Processor Results

Particle size analysis is often used to evaluate polymer nanoparticles. Utilizing specific analytical techniques, including dynamic light scattering, optical microscopy, and SEM or TEM, we have found that Microfluidizer® technology is able to reduce polymer droplet size significantly after several passes.

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