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  • Microfluidics offers technologies to meet the variable and demanding needs for cell disruption, from gentle disruption of cultured mammalian cells to the challenging disruption of yeast and other fungi. The advantages of Microfluidizer processors for cell disruption are hard to ignore. Here are some of the benefits of this high-yield cell lysis technology: Easy to Use and Low Maintenance Customers that use our...
  • Microfluidizers are the ideal equipment for cell disruption. In fact, in previous blog posts we’ve reviewed various cell lysis techniques and the advantages of Microfluidizer technology for cell disruption. In this post, we share our tips for using a Microfluidizer for lysis. Tip #1: Do not over-mix the pre-mix. Using a vortex mixer can entrap air in the cell suspension, which will choke the Microfluidizer. This...
  • Techniques for cell disruption are not all created equal. Results published in the scientific literature show the cell disruption method strongly influences the physical-chemical properties of the disintegrate, such as particle size, disruption efficiency, viscosity and protein release. Here’s an overview of some of the more common cell disruption technologies. You’ll notice a common theme: Microfluidizers provide...
  • Cell-based assays for high throughput screening represent an exciting new frontier in the race to discover and develop tomorrow’s new blockbuster drugs. This paradigm-shifting technology can be used to harness the potential of single mammalian cells, encapsulated with appropriate reagents, to serve as microreactors. When combined with high throughput screening, this allows for the rapid evaluation of unprecedentedly...
  • Cancer is the second-leading cause of mortality worldwide, and the number of annual deaths continues to rise. From 2005 to 2015, for instance, cancer cases rose by 33 percent in a majority of countries. While some of this troubling increase may be attributed to overall growth in population and aging, it’s clear that the need has never been greater for effective chemotherapy drugs and other cancer therapies....
  • For decades, scientists have pursued the production of nanoparticles to enhance the bioavailability and stability of drugs and cosmeceuticals. Owing to their vanishingly small particle sizes, so-called “nanomedicines” possess significantly higher dissolution rates than their macro analogues. This characteristic is especially desirable when the molecule in question suffers from poor water solubility. In recent years...
  • Pharmaceutical industry prognosticators recognize that liposomes will play an increasingly important role in the development of new drugs for the foreseeable future, due to the unique drug-delivery advantages these designer entities offer. With a heterogenous bilayer encapsulating an aqueous interior core, liposomes are ideal vesicles for the delivery of pharmacological payloads consisting of a hydrophilic compound...
  • Since the eradication of smallpox nearly four decades ago, the quest to develop effective vaccines for any number of other diseases has benefitted from significant advances in medical science and technology. In subsequent years, various methods of vaccine delivery have been pioneered. Modern vaccine development goals include improved efficacy, reduced risk, enhanced safety and better stability of vaccines; as well...
  • The Relative Efficiency Of Microfluidizer Vs. High Pressure Homogenizer Technology To Create Stable Nanoemulsions Emulsions are effective vehicles for the delivery of bioactive compounds. Accordingly, these microscopic mixtures of droplets composed of otherwise immiscible liquids are of great importance to industries such as pharmaceuticals, cosmetics and food. The challenge for process engineers within these...
  • Nanotechnology is small. So small, it defies the imagination's ability to grasp. By definition, working with nanotechnology involves operating on an infinitesimally small scale — less than 100 nanometers, to be precise. For scientists accustomed to working on the scale of millimeters — or even micrometers — the switch to nano scale involves orders of magnitude of difference, as the manipulation of matter is carried...
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