Inhalation therapy has been used to deliver various pharmaceutical preparations directly to the lungs for more than a century. Primarily targeting lung-related conditions such as asthma, cystic fibrosis or chronic obstructive pulmonary disease (COPD), these aerosol-based treatments delivered medications deep into the lungs and alveoli, providing rapid onset of action.
More recently, inhalation therapy has been...
Milk homogenization has been practiced for more than a century. Milk comes from the source as a more or less natural emulsion. The milk protein, casein, forms an emulsifying membrane that stabilizes milk fat in its aqueous matrix. But milk fat, in the form of cream, quickly rises to the top once this nutritious beverage leaves the cow. Homogenization serves to prevent fat globules from separating and rising to the...
For years, the writing has been on the wall: The golden age of blockbuster drugs was fun while it lasted, but it is ultimately unsustainable. For starters, these drugs tend to provide therapeutic benefits to only a select proportion of the patients who take them.
Indeed, within more than a dozen therapeutic categories, patient response rates to the great majority of “standard” drug therapies do not reach 60 percent...
Liposomes are artificially created, microscopic, spherical structures that take a page from na-ture to exploit certain useful properties found in living cells. Their design enables them to excel at the targeted delivery of payloads, such as chemotherapeutic drugs delivered to tumor cells. Their defining characteristic is a lipid bilayer, consisting of phospholipids, such as phosphatidyl-choline, which encase one or...
Particle size reduction is a key process many industries use to transform bulky or randomly sized substances into uniformly sized, far smaller particles suitable for a wide range of applications. When done correctly, particle size reduction favorably alters certain key physiochemical properties of the raw material(s). The ultimate success of a given process
often depends on this precise size...
Scientists use innovative delivery systems to tailor omega-3 digestion speed
Flaxseed oil encapsulated in nanoememulsions displayed a much more rapid digestion than when hydrogel beads(HB) were used, found a recent study published in Food Research International.
How rugby injury and ‘fishy burps’ inspired new health drink
When Marcus Mollinga was recovering from surgery after a rugby injury, he was encouraged to...
Here’s a roundup of news and trends in the pharmaceutical manufacturing industry, gleaned from various industry publications:
How Combination Product Manufacturers Improve Their Technology Through Process Scale-Up
Eric Resnick, Vice President and Chief Technology Officer, West Pharmaceutical Services, Inc., discusses how the introduction of biologic therapies has forced drug delivery manufacturers to take a more...
Microfluidics offers technologies to meet the variable and demanding needs for cell disruption, from gentle disruption of cultured mammalian cells to the challenging disruption of yeast and other fungi.
The advantages of Microfluidizer® processors for cell disruption are hard to ignore. Here are some of the benefits of this high-yield cell lysis technology:
Easy to Use and Low Maintenance
Customers that use our...
Microfluidizer® processors are the ideal equipment for cell disruption. In fact, in previous blog posts we’ve reviewed various cell lysis techniques and the advantages of Microfluidizer technology for cell disruption. In this post, we share our tips for using a Microfluidizer® processor for lysis.
Tip #1: Do not over-mix the pre-mix.
Using a vortex mixer can entrap air in the cell suspension, which will choke the...
Techniques for cell disruption are not all created equal. Results published in the scientific literature show the cell disruption method strongly influences the physical-chemical properties of the disintegrate, such as particle size, disruption efficiency, viscosity and protein release.
Here’s an overview of some of the more common cell disruption technologies. You’ll notice a common theme: Microfluidizer®...