Microfluidics Technology And Equipment
In recent years, diverse industries have embraced microfluidizer technology for the creation of products with qualities that are only possible using nano-scale materials. Examples include nanoparticles, nanoemulsions and nanoencapsulation.
Advantages of this emerging technology are numerous, and include everything from improved stability, to optimized characteristics, to enhanced delivery of hydrophobic drugs to their intended targets, to improved protection of payload molecules from oxidation, among other improvements. This technology is also instrumental in the production of timed-release products, such as drugs, cosmetics, nutraceuticals and even pesticides/herbicides.
Microfluidics Applications and Techniques
It’s no wonder, then, that process engineers in industries as distinct as pharmaceuticals, fine chemicals, biotechnology, cosmetics, food processing and energy have discovered that microfluidic techniques represent superior technology for the efficient creation of nanoparticles and nanoemulsions, among other applications.
Although conventional homogenizers can also be used to achieve some of these applications, Microfluidics Microfluidizer® machines offer superior results in terms of greater particle size reductions, tighter particle size distributions, repeatability and seamless scalability.
Microfluidizer technology ensures that fluid pressure is converted to high shear forces more efficiently and consistently than is readily achievable using competing technologies. By maintaining constant pressure, Microfluidizer® homogenizers ensure that 100 percent of a given material receives exactly the same treatment.
Inherent differences in microfluidic techniques versus high-pressure valve homogenization technology mean far less process energy is converted to heat. This not only saves energy, but it also helps prevent thermal effects from altering the physiochemical characteristics of any delicate materials undergoing processing.
Liposomes, Nanoemulsions, Nanoencapsulation and More
The key to our remarkable efficiency is the design of our exclusive fixed-geometry Microfluidizer® interaction chamber. As fluids are forced at constant pressures and controlled temperatures through the unique interaction chamber, materials experience extreme shear forces, yielding precisely controlled particle size reductions and strikingly tight particle size distribution curves. The ability to control the level of shearing provides customers the flexibility to use less energy to achieve particle size reduction targets — which are often smaller than those possible using ordinary homogenizer technologies.
Needless to say, it’s one thing to develop an effective process during the research and development phase, while it is often another thing entirely to attempt to scale up that process to full production-run volume. By ensuring guaranteed scale-up success, Microfluidics provides customers the ability to sidestep this common potential pitfall.
Whether you use our carefully engineered machines to achieve cell disruption, nanoemulsions, nanoencapsulation, liposomes, or some other cutting-edge application, you can depend on Microfluidics Microfluidizer® technology to deliver the particle size reductions you require, more efficiently and more consistently, regardless of where you are in the development process for your droplet microfluidics applications.
Groundbreaking Achievements For Liposome Creation
Liposome production provides an excellent example of what’s possible using Microfluidics Microfluidizer® technology. As noted in an issue of “Methods in Enzymology,” microfluidics is an emerging technology for liposome creation, which offers precise control of the lipid hydration process. These artificial structures mimic natural biological vesicular structures typically located within the cytoplasm of living cells. They feature one or more lipid bilayers surrounding an aqueous core.
These created structures are often ideal for the targeted delivery of bioactive molecules, such as pharmaceuticals. The aqueous interior can be impregnated with a hydrophilic drug or drugs, while the lipid bilayers can transport lipophilic and amphiphilic drugs. Tailored specifically to penetrate the barrier posed by the cells’ own membrane bilayer, these artificial structures function as virtual smart bombs for drug delivery.
Created using nano-sized particles, artificial liposomes can be used to enhance a range of key pharmacokinetic variables, including drug half-life, toxicity and target cell/tissue specificity, among others. Most recently, investigators reported in the journal “Interface Focus,” droplet-based microfluidics is being harnessed in pursuit of the creation of protocells and artificial cells.
Contact our knowledgeable sales staff for more information about this and other technology-forward applications achievable using groundbreaking Microfluidizer® technology. Contact us here, fill out the online form to request a quote, or call directly: 1-800-370-5452. (International customers call: +1-617-969-5452)